ANGIOGUARD RX Emboli Capture Guidewire System
The Problem: Distal Embolization During Carotid Stenting
Carotid artery stenting carries an inherent risk of distal embolization — debris liberated from the plaque during stent deployment can travel intracranially and cause periprocedural stroke, which is the outcome the intervention is itself designed to prevent. Embolic protection is not optional; it is the standard of care.
The ANGIOGUARD RX Solution
The ANGIOGUARD RX Emboli Capture Guidewire System is Cordis’s flagship distal emboli protection device, demonstrated in the landmark SAPPHIRE trial to achieve a 70% relative reduction in stroke risk during carotid artery stenting compared to carotid endarterectomy in high-surgical-risk patients.
The ANGIOGUARD RX combines an 0.014” guidewire with a filter basket deployed distal to the treatment zone before stent delivery. The porous filter captures embolic debris with particle diameters of 100 microns and above while maintaining distal perfusion throughout the procedure — unlike balloon occlusion protection systems. The filter basket is self-expanding and adapts to vessel diameters from 3.5 mm to 7.5 mm, covering the clinically relevant range of internal carotid artery dimensions. Following stent deployment, the capture catheter sheaths the loaded filter basket for retrieval without spilling debris into the distal circulation.
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Clinical Specifications
| Field | Specification |
|---|---|
| Protection Mechanism | Distal filter basket; captures embolic debris while maintaining distal perfusion (no flow arrest) |
| Wire Diameter | 0.014” |
| Filter Pore Size | 100 microns — captures particles ≥100 μm |
| Vessel Diameter Range | 3.5 mm – 7.5 mm (internal carotid artery range) |
| Perfusion Maintained During Use | Yes — porous filter design maintains antegrade flow throughout procedure |
| Trial Evidence | SAPPHIRE trial — 70% relative reduction in stroke risk vs. carotid endarterectomy in high-surgical-risk patients |
| Regulatory Status | FDA-approved; CE Mark |